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Updated: Sep 28, 2026
Mouse Models of Periventricular Leukomalacia
Published on: May 18, 2010
[Visuo-constructive disorders in periventricular leukomalacia]
1Servicio de Neurología, Unitat Integrada Clínic-Sant Joan de Déu, Barcelona, Spain. annasans@hsjdbcn.org
Insights
Children with periventricular leukomalacia often experience visuospatial difficulties. These challenges are linked to constructional dyspraxia and reduced white matter in the parietal lobe.
Area of Science:
- Neurology
- Developmental Pediatrics
- Neuroscience
Context:
- Cerebral palsy (CP) encompasses motor and cognitive impairments.
- Visuospatial deficits are common in preterm children with spastic diplegia, often resulting from periventricular leukomalacia (PVL).
Purpose:
- To investigate the prevalence and nature of visuospatial anomalies in children with periventricular leukomalacia.
- To explore the relationship between these anomalies and specific brain structural changes.
Summary:
- This study examined eight children diagnosed with periventricular leukomalacia, aged 3 to 13 years.
- All participants exhibited visuospatial anomalies.
- These visuospatial issues did not impede reading or writing acquisition.
Impact:
- Constructional dyspraxia is a frequent finding in children with PVL.
- The severity of constructional dyspraxia correlates with reduced peritrigonal white matter volume in the parietal lobe.
- Findings highlight the importance of assessing visuospatial function in children with PVL for targeted interventions.
Introduction:
Cerebral palsy involves not only motor impairment but also the impairment of cognitive functions. Visuo spatial impairment has often been reported in preterm children with spastic diplegia due to periventricular leukomalacia.
Patients And Methods:
Eight children with periventricular leukomalacia diagnosis. When examined their ages were between 3 and 13 years.
Results:
We found visuo spatial anomalies in all subjects. These anomalies don't result in reading and writing learning difficulties.
Conclusion:
Constructional dyspraxia is frequently found in children with periventricular leukomalacia and correlates with reduction of peritrigonal white matter in parietal lobe.
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