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Cognitive stimulation has potential for brain activation in individuals with Rett syndrome.
C Migliorelli1,2,3, I Medina-Rivera3,4, A Bachiller1,3
1Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB), Universitat Politècnica de Catalunya (UPC), Barcelona, Spain.
Journal of Intellectual Disability Research : JIDR
|November 19, 2021
Summary
Cognitive stimulation using eye-tracking tasks altered brain rhythms in girls with Rett syndrome (RS), showing lasting effects and improved brain symmetry, especially in younger children.
Area of Science:
- Neuroscience
- Developmental Psychology
- Biomedical Engineering
Background:
- Limited knowledge exists on neuropsychological training for Rett syndrome (RS).
- Assessing cognitive stimulation's effects on electroencephalography (EEG) in RS is crucial.
Purpose of the Study:
- To evaluate the immediate and lasting effects of cognitive stimulation on EEG in female children with RS.
- To investigate changes in brain activity and symmetry during and after an eye-tracking cognitive task.
Main Methods:
- Twenty female children with RS performed an eye-tracking cognitive task.
- Topographic EEG data were recorded during baseline, task performance, and post-task periods.
- Analysis focused on EEG spectral markers, including Brain Symmetry Index (BSI) and entropy.
Main Results:
- Cognitive stimulation led to decreased delta activity and increased beta rhythm.
- Entropy increased during and after the task, indicating heightened brain activity.
- A positive interaction between BSI and age showed greater symmetry improvement in younger girls (5-10 years).
Conclusions:
- Cognitive stimulation significantly alters brain rhythms in RS, with effects extending beyond the stimulation period.
- The eye-tracking task promoted increased brain symmetry, particularly beneficial for younger individuals.
- Further research is needed to explore the relationship between brain asymmetries and age in RS.
