DNA repair: insights from urinary lesion analysis
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Updated: Sep 28, 2026

Cell-Free DNA Integrity Analysis in Urine Samples
Published on: January 5, 2017
Marcus S Cooke1, Mark D Evans, Joseph Lunec
1Oxidative stress Group, Department of Clinical Biochemistry, University of Leicester, RKCSB, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE2 7LX, UK. msc5@le.ac.uk
Abstract:
Due to various confounding factors, namely dietary contribution and cell death, measurement of urinary 8-oxo-2'-deoxyguanosine (8-oxodG) has long been considered to be no more than a marker of generalised oxidative stress. Indeed, the action of no single enzyme has been reported to excise 8-oxodG from DNA. However, analysis of recent research has suggested that these confounders may be circumvented, which, combined from work from the authors' laboratory, indicates that urinary 8-oxodG has the potential to become a most important marker of oxidative damage to, and repair of, DNA.
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