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Membrane viscoelasticity.

E A Evans, R M Hochmuth

    Biophysical Journal
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    The viscoelastic behavior of red blood cell membranes is primarily governed by membrane viscosity, not fluid flow. A structural matrix, not the lipid bilayer, dominates viscous dissipation in these cells.

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    Area of Science:

    • Biophysics
    • Cell Biology
    • Materials Science

    Background:

    • Red blood cell membranes exhibit complex viscoelastic properties crucial for their function.
    • Understanding these properties is key to diagnosing and treating various hematological disorders.

    Purpose of the Study:

    • To develop a theoretical framework for analyzing large membrane deformations in viscoelastic materials.
    • To apply this theory to understand the relaxation dynamics of red blood cells after micropipette aspiration.

    Main Methods:

    • Development of a new theory for viscoelastic behavior of large membrane deformations.
    • Application of the theory to analyze relaxation processes in red blood cell discocytes subjected to micropipette aspiration.

    Main Results:

    Related Experiment Videos

    • Membrane viscosity, not cytoplasmic or extracellular fluid flow, dominates the relaxation time of aspirated red blood cells.
    • Estimated total membrane viscosity is 10(-3) dyn-s/cm, significantly higher than lipid membrane components.
    • A structural matrix, rather than the lipid bilayer, is the primary contributor to viscous dissipation.

    Conclusions:

    • The lipid bilayer plays a minimal role in the fluid dynamic behavior of the red blood cell plasma membrane.
    • A structural matrix within the membrane is the dominant factor in viscous dissipation.
    • Previous estimates of membrane viscosity for lysis are significantly overestimated.