Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Membrane viscoplastic flow.

E A Evans, R M Hochmuth

    Biophysical Journal
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    The study reveals red blood cell membranes have a structural matrix that dominates flow, with a yield shear significantly lower than lysis tension. This explains microtether flow behavior.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical experience across the fetal-fraction spectrum of a non-invasive prenatal screening approach with low test-failure rate.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019
    Same author

    High-voltage SPM oxidation of ZrN: materials for multiscale applications.

    Nanotechnology·2011
    Same author

    Enzyme systems operating within the malarial parasite.

    Federation proceedings·2010
    Same author

    The biochemistry of the malaria parasite; the in vitro effects of x-rays upon Plasmodium gallinaceum.

    The Journal of infectious diseases·2010
    Same author

    The biochemistry of the malaria parasite; mechanism of pyruvate oxidation in the malaria parasite.

    The Journal of biological chemistry·2010
    Same author

    The biochemistry of the malaria parasite; studies on the nitrogen metabolism of the malaria parasite.

    The Journal of biological chemistry·2010
    Same journal

    Heterogeneous binding of SARS-CoV2 fusion peptide on complex cellular membranes enhances its fusogenicity.

    Biophysical journal·2026
    Same journal

    Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.

    Biophysical journal·2026
    Same journal

    Emergent Intercellular Junction Stability during Cyclic Tissue Loading.

    Biophysical journal·2026
    Same journal

    Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

    Biophysical journal·2026
    Same journal

    Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

    Biophysical journal·2026
    Same journal

    Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

    Biophysical journal·2026
    See all related articles

    Area of Science:

    • Biophysics
    • Materials Science
    • Cell Biology

    Background:

    • Red blood cell membranes exhibit complex mechanical properties beyond simple elasticity.
    • Understanding membrane deformation is crucial for comprehending cellular mechanics and disease states.
    • Previous models often simplified membrane behavior, neglecting viscoplastic contributions.

    Purpose of the Study:

    • To develop and apply a viscoplasticity theory to analyze red blood cell microtether flow.
    • To determine the intrinsic material constants governing membrane viscoplastic behavior.
    • To elucidate the dominant mechanisms of fluid dissipation in stretched red blood cell membranes.

    Main Methods:

    • Applied Prager and Hohenemser's viscoplasticity theory to a two-dimensional membrane model.

    Related Experiment Videos

  • Analyzed experimental data from microtethers pulled from red blood cells on glass substrates.
  • Calculated intrinsic material constants: yield shear and surface viscosity.

    • Main Results:

    • Calculated intrinsic viscosity for plastic flow of the membrane to be 1 x 10^-2 dyn-s/cm.
    • Determined yield shear in the range of 2-8 x 10^-2 dyn/cm.
    • Found intrinsic viscosity to be orders of magnitude greater than lipid component surface viscosities, indicating a structural matrix dominates dissipation.

    Conclusions:

    • Fluid dissipation in red blood cell microtethers is primarily governed by a structural matrix exceeding its yield shear.
    • The yield shear of the membrane is significantly lower than the tension required to lyse red blood cells.
    • The developed viscoplasticity model provides a more accurate description of red blood cell membrane mechanics under stress.