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MMP-9 correlates with electrophysiologic abnormalities in Guillain-Barré syndrome
T Sharshar1, M-C Durand, J-P Lefaucheur
1Réseau de Neuroimmunologie du Nerf Périphérique, Université de Paris, France.
Neurology
|November 27, 2002
Abstract:
To investigate the role of MMP-9 in Guillain-Barré syndrome, the authors correlated electrophysiologic abnormalities and MMP-9 plasma levels in a series of 21 patients. MMP-9 plasma levels were higher in the demyelinating group than in the nondemyelinating group, and in patients with high CSF protein level. Increase of MMP-9 circulating levels correlated with the increase of F waves latencies, reduction of CMAP amplitude, and decrease of nerve conduction velocities. Circulating MMP-9 may contribute to the peripheral nerve dysfunction of demyelinating Guillain-Barré syndrome.