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[Blood flow in cerebral aneurysms].

U Kertzscher1, L Goubergrits, A Spuler

  • 1Labor für Biofluidmechanik, Klinik für Kardiovaskuläre Chirurgie, Charité, Humboldt Universität zu Berlin, Deutschland. ulrich.kertzscher@charite.de

Biomedizinische Technik. Biomedical Engineering
|November 28, 2002
PubMed
Summary

Cerebral aneurysms affect 1-5% of people, with rupture causing deadly subarachnoid hemorrhage. Simulating blood flow in four aneurysms revealed diverse flow patterns, aiding treatment method selection.

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Area of Science:

  • Biomedical Engineering
  • Neurosurgery
  • Fluid Dynamics

Background:

  • Saccular cerebral aneurysms affect 1-5% of the population.
  • Aneurysm rupture leads to subarachnoid hemorrhage with 50-60% mortality.
  • Treatment options include neurosurgical clipping and endovascular coiling, each with pros and cons.

Purpose of the Study:

  • To simulate blood flow patterns within four distinct saccular cerebral aneurysms.
  • To investigate how aneurysm geometry influences hemodynamics.
  • To provide data that may aid in selecting optimal treatment strategies for cerebral aneurysms.

Main Methods:

  • Utilized patient-specific aneurysm geometries derived from computed tomographic (CT) data.
  • Performed computational fluid dynamics (CFD) simulations to model blood flow.

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  • Analyzed hemodynamic parameters within the aneurysm sac and at the neck.

    • Main Results:

    • Demonstrated significant variability in intra-aneurysmal flow patterns across the four studied geometries.
    • Identified distinct flow recirculation zones and wall shear stress distributions.
    • Highlighted the influence of aneurysm shape and neck dimensions on flow dynamics.

    Conclusions:

    • Intra-aneurysmal hemodynamics are highly variable and geometry-dependent.
    • Understanding patient-specific flow patterns can inform treatment decisions for cerebral aneurysms.
    • CFD simulations offer valuable insights into aneurysm behavior and rupture risk.