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Related Experiment Videos

Glucose intolerance with atypical antipsychotics.

Karin Hedenmalm1, Staffan Hägg, Malin Ståhl

  • 1Drug Epidemiology Unit, Medical Products Agency, Uppsala, Sweden. karin.hedenmalm@mpa.se

Drug Safety
|November 28, 2002
PubMed
Summary

Atypical antipsychotics like clozapine, olanzapine, and risperidone are linked to a higher risk of glucose intolerance and diabetes. Risk factors include pre-existing diabetes, weight gain, male gender, and use of certain other medications.

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Association Between Levels of the Acute Phase Proteins Alpha-1-Acid Glycoprotein and C-Reactive Protein and Serum Concentrations of Clozapine: A Study of 1106 Therapeutic Drug Monitoring Samples.

Basic & clinical pharmacology & toxicology·2026

Area of Science:

  • Pharmacovigilance
  • Metabolic Disorders
  • Psychiatric Pharmacology

Background:

  • Previous research indicated potential links between atypical antipsychotics (clozapine, olanzapine) and increased risks of glucose intolerance and diabetes mellitus.
  • Early studies also suggested a correlation between conventional antipsychotic use and the development of glucose intolerance.

Purpose of the Study:

  • To quantitatively assess the association between glucose intolerance (including diabetes mellitus) and the use of atypical antipsychotics: clozapine, olanzapine, and risperidone.
  • To identify potential risk factors contributing to glucose intolerance during treatment with these specific antipsychotic medications.

Main Methods:

  • Utilized the World Health Organization (WHO) database for adverse drug reactions to identify reports of glucose intolerance associated with clozapine, olanzapine, and risperidone.

Related Experiment Videos

  • Employed the Bayesian Confidence Propagation Neural Network (BCPN) method to analyze the strength of associations over time.
  • Compared these associations with those of conventional antipsychotics (haloperidol, chlorpromazine) and other adverse drug reaction reports.

    • Main Results:

    • Clozapine, olanzapine, and risperidone demonstrated a significant association with glucose intolerance, unlike chlorpromazine and haloperidol.
    • Identified risk factors for glucose intolerance with these atypical antipsychotics included: pre-existing diabetes (OR 10.22), weight increase (OR 2.36), male gender (OR 1.27), and concurrent use of valproic acid (OR 1.97), SSRIs (OR 1.63), or buspirone (OR 2.24).

    Conclusions:

    • Treatment with clozapine, olanzapine, or risperidone is associated with an elevated risk of developing glucose intolerance.
    • Understanding these risk factors is crucial for managing patients on these antipsychotic medications.