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Lipoprotein lipase: genetics, lipid uptake, and regulation
Martin Merkel1, Robert H Eckel, Ira J Goldberg
1Department of Medicine, University of Hamburg, Hamburg, Germany. Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA.
Journal of Lipid Research
|November 28, 2002
Abstract:
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.