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Updated: Jul 11, 2026
Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact
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[Induction of murine bone marrow stromal cell differentiation into nerve cells]
Iu E Shchegel'skaia1, Iu E Mikulinskiĭ, A V Revishchin
1Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of the Ukraine, Kharkov.
Abstract:
The in vitro induced differentiation of mouse bone marrow stromal cells into nerve cells by retinoic acid and leukemia inhibitory factor has been shown, using morphological, histochemical and immunocytochemical analyses. The developed techniques allow to obtain up to 30% of neural cells in vitro. A suggestion about pluripotency of bone marrow stromal cells and possibility of their application to the cell therapy is discussed.
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