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Molecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea
Sze Chung Clive Lo1, Lisbeth Hamer, John E Hamer
1Microbial Research, Paradigm Genetics, Inc., Research Triangle Park, North Carolina 27709, USA. clo@paragen.com
Eukaryotic Cell
|November 29, 2002
Abstract:
CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine beta-synthase (CBS) gene from Saccharomyces cerevisiae. Our studies indicated that M. grisea can utilize homocysteine and methionine through a CBS-independent pathway. The results also revealed responses of M. grisea to homocysteine that are reminiscent of human homocystinuria.