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Updated: Jul 1, 2026

Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples
Published on: October 1, 2016
Capillary electrophoresis-inductively coupled plasma-mass spectrometry: an attractive complementary technique for
Sasi S Kannamkumarath1, Katarzyna Wrobel, Kazimierz Wrobel
1Department of Chemistry, Mail location 0172, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Abstract:
Some basic and practical aspects of interfacing capillary electrophoresis to inductively coupled plasma-mass spectrometry (CE-ICP-MS) are reviewed in this article with emphasis on the use of this hyphenated technique for elemental speciation analysis. The principles behind the techniques of both CE and ICP-MS are introduced. The interfacing of CE to ICP-MS is discussed including several devices and nebulizers reported in literature. A brief account of their advantages and limitations is given. The various CE-ICP-MS applications for elemental speciation analysis are also reviewed. Some issues concerning the future of CE-ICP-MS for the elemental speciation analyses are discussed.
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