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Bulbourethral Gland Cysts in Three Mice
Craig L. Wardrip1, Jeffrey J. Lohmiller, Sonya P. Swing
1Department of Surgery and the Committee on Comparative Medicine and Pathology, The University of Chicago, Chicago, IL 60637.
Contemporary Topics in Laboratory Animal Science
|November 29, 2002
Summary
Bulbourethral gland cysts are uncommon in mice. This report details three cases of these perineal nodules, suggesting they should be considered in mouse diagnoses.
Area of Science:
- Veterinary Pathology
- Mouse Models
- Glandular Diseases
Background:
- Diseases affecting the bulbourethral glands in mice are infrequently documented.
- Perineal nodules or swellings in mice can have various etiologies.
Purpose of the Study:
- To describe the pathological findings of bulbourethral gland cysts in three distinct mouse models.
- To highlight bulbourethral gland cysts as a differential diagnosis for perineal masses in mice.
Main Methods:
- Histopathological examination of perineal nodules from three male mice (DBA/2J, nude, and chimeric).
- Gross and microscopic analysis of nodule morphology, location, and cellular composition.
Main Results:
- Three cases of subcutaneous bulbourethral gland cysts were identified on the dorsal perineum.
- Nodules varied in size (6-13 mm) and fluid content (clear gelatinous to blood-tinged).
- Histology revealed irregular cysts and acini lined by cuboidal to columnar epithelium.
Conclusions:
- Bulbourethral gland cysts represent a rare but distinct pathological entity in mice.
- These cysts should be included in the differential diagnosis for perineal nodules or swellings observed in mice.