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Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Noninvasive assessment of cardiovascular risk: from Framingham to the future

R A Vogel1, R M Benitez

  • 1University of Maryland School of Medicine, Baltimore, USA.

Reviews in Cardiovascular Medicine
|November 29, 2002
PubMed

Insights

Cardiovascular disease management relies on risk assessment. New markers like high-sensitivity C-reactive protein, arterial stiffness, and ankle-brachial index show promise for improved population screening and risk prediction.

Area of Science:

  • Cardiology and Atherosclerosis Research

Background:

  • Cardiovascular disease (CVD) management increasingly utilizes risk assessment and factor modification.
  • The Framingham Study provided foundational risk assessment, but more precise markers are needed.
  • Ongoing research evaluates markers related to thrombosis, endothelial dysfunction, and plaque formation.

Purpose of the Study:

  • To identify and evaluate novel, precise markers for cardiovascular disease risk assessment.
  • To explore potential biomarkers for population screening beyond traditional methods.

Main Methods:

  • Review and evaluation of emerging markers in atherosclerosis development.
  • Focus on markers amenable to population screening.

Main Results:

  • High-sensitivity C-reactive protein (hs-CRP) tests are promising for inflammation assessment.
  • Arterial stiffness, measured directly or via pulse pressure, indicates vascular health.
  • Ankle-brachial index (ABI) is a valuable tool for peripheral artery disease screening.

Conclusions:

  • hs-CRP, arterial stiffness, and ABI represent key advancements in cardiovascular risk stratification.
  • These markers offer potential for more accurate population screening and early detection of CVD risk.

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