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Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection
Heather E Fleming1, Christopher J Paige
1Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Department of Immunology, University of Toronto, 610 University Avenue, 7-504 Toronto, Ont., Canada M5G 2M9. heatherf@uhnres.utoronto.ca
Abstract:
Hematopoiesis is regulated by a variety of signals that either originate within a developing cell or are supplied by the surrounding environment in secreted- or contact-dependent forms. This review discusses the effects of one secreted factor, interleukin-7, on the development of B lymphocytes. We describe a molecular mechanism for a crucial checkpoint during B lineage maturation, based on the integration of signals mediated by the pre-B cell receptor, the interleukin-7 receptor, and the environment in which these signals are received.
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