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Reproductive toxicity of ergot alkaloids in mink.

C Sharma1, R J Aulerich, J A Render

  • 1Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.

Veterinary and Human Toxicology
|December 3, 2002
PubMed
Summary
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Ergot alkaloids in mink diets caused reproductive toxicity. Doses of 3 ppm or higher significantly reduced mink whelping and kit survival, impacting ranch mink health.

Area of Science:

  • Veterinary Toxicology
  • Animal Reproduction
  • Mycotoxicology

Background:

  • Ergot alkaloids, produced by Claviceps fungi, contaminate cereals like oats.
  • Ranch mink diets include cereals, posing a risk of ergot alkaloid exposure.
  • Reproductive toxicity of ergot alkaloids in mink is not well-documented.

Purpose of the Study:

  • To determine the reproductive toxicity of ergot alkaloids from contaminated oats in mink.
  • To establish a dose-response relationship for ergot alkaloid exposure in mink reproduction.

Main Methods:

  • Four groups of 12 female mink were fed diets with 0, 3, 6, or 12 ppm ergot alkaloids.
  • Exposure occurred from 2 weeks pre-breeding through kit weaning (133 days).
  • Reproductive parameters including whelping rates, gestation length, kit survival, and serum prolactin were assessed.

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Main Results:

  • Ergot alkaloids caused a transient decrease in feed consumption; body weight was unaffected.
  • Whelping rates significantly decreased at 6 ppm (4/12) and 12 ppm (1/12) compared to controls (9/12).
  • Kit survival was severely impacted, with no survival at 12 ppm; serum prolactin levels were depressed at 3 ppm and higher.

Conclusions:

  • Ingestion of ergot alkaloids at 3 ppm or higher resulted in significant reproductive toxicity in mink.
  • Ergot alkaloid exposure negatively affects mink fertility and kit survivability.
  • These findings highlight the risk of ergot-contaminated feed for mink farming.