Related Experiment Videos
A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity
Sven Guenther1, Jan Balzarini, Erik De Clercq
1Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA.
Journal of Medicinal Chemistry
|December 3, 2002
Abstract:
(E)-5-(2-Bromovinyl)isodideoxyuridine (BVisoDDU), synthesized on the basis of molecular modeling, is selectively active against HSV-1 (three different strains) but inactive against HSV-2. Unlike BVDU, BVisoDDU is completely resistant to cleavage by thymidine phosphorylase. BVisoDDU is also the first nucleoside analogue lacking OH groups at both the 2'- and 3'-position that shows pronounced activity against HSV-1 replication.