Related Experiment Video

Updated: Sep 11, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

[Cerebral vasculitis]

P Berlit1, A Steinbrecher

  • 1Neurologische Klinik Alfried Krupp Krankenhaus Essen. peter.berlit@krupp-krankenhaus.de

Fortschritte Der Neurologie-Psychiatrie
|December 3, 2002
PubMed

Insights

This review covers central nervous system (CNS) vasculitis, a condition often presenting with neurological symptoms. Diagnosis requires a biopsy, and treatment involves corticosteroids and cyclophosphamide.

Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Context:

  • Central nervous system (CNS) vasculitis involves inflammation of blood vessels in the brain.
  • Systemic vasculitides and collagen vascular diseases can affect the CNS.

Purpose:

  • To review the diagnosis and treatment of isolated CNS-angiitis and cerebral involvement in systemic vasculitides.
  • To highlight diagnostic challenges and therapeutic strategies.

Summary:

  • CNS vasculitis symptoms include headache, multifocal neurological deficits, and encephalopathy.
  • Diagnosis relies on MRI, angiography, CSF, and serum analysis, but a biopsy is often essential for confirmation, except in Behçet's syndrome.
  • The primary treatment involves a combination of corticosteroids and cyclophosphamide.

Impact:

  • Provides a comprehensive overview for clinicians managing CNS vasculitis.
  • Emphasizes the importance of timely diagnosis and appropriate immunosuppressive therapy.
  • Contributes to understanding the management of rare but serious neurological conditions.

More Related Videos

Isolation and Cannulation of Cerebral Parenchymal Arterioles09:49

Isolation and Cannulation of Cerebral Parenchymal Arterioles

Published on: May 23, 2016

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...