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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

[Apoptosis and cardiovascular disease]

Hakan Kültürsay1, Meral Kayikçioğlu

  • 1Department of Cardiology, Medical Faculty, Ege University, Izmir, Turkey. omkay@superonline.com

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|December 4, 2002
PubMed

Insights

Genetically programmed cell death, or apoptosis, is crucial in heart development and disease. Modulating apoptotic factors may prevent cardiovascular disease progression.

Area of Science:

  • Cardiovascular Science
  • Cell Biology
  • Molecular Biology

Context:

  • Apoptosis, a fundamental biological process, is integral to cardiac development.
  • Dysregulation of apoptotic pathways is implicated in the pathogenesis of cardiovascular diseases.

Purpose:

  • To review the fundamental mechanisms of apoptosis in the heart.
  • To explore the role of apoptosis in cardiovascular disease development.
  • To evaluate the clinical applications of targeting apoptosis in cardiac conditions.

Summary:

  • This review elucidates the key features of apoptosis, a genetically programmed cell death.
  • It highlights the significance of extrinsic and intrinsic factors influencing apoptosis during cellular events.
  • The pathogenetic role of apoptosis in heart disease and its clinical implications are critically examined.

Impact:

  • Understanding apoptosis mechanisms offers potential therapeutic targets for cardiovascular diseases.
  • Modulating apoptotic pathways could be a novel strategy for preventing cardiac disease progression.
  • This knowledge can inform clinical practice for managing heart conditions involving cell death.

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