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Hurthle cell neoplasms of the thyroid
Linda D Dahl1, David Myssiorek, Keith S Heller
1Department of Otolaryngology, Long Island Jewish Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA.
The Laryngoscope
|December 4, 2002
Summary
Intraoperative frozen-section analysis has low reliability for diagnosing Hurthle cell carcinoma, with only 19% accuracy. Men with Hurthle cell neoplasm are more likely to have malignancy than women.
Area of Science:
- Endocrinology
- Surgical Pathology
- Oncology
Background:
- Hurthle cell tumors are a subset of follicular cell neoplasms in the thyroid.
- Accurate intraoperative diagnosis is crucial for guiding surgical management.
Purpose of the Study:
- To assess the diagnostic reliability of intraoperative frozen-section analysis for Hurthle cell carcinoma and neoplasm.
- To investigate demographic and tumor-specific factors associated with Hurthle cell carcinoma incidence.
Main Methods:
- Retrospective chart review of thyroid surgery patients from 1990-2000.
- Analysis of patient demographics (age, gender), tumor size, and frozen-section versus final pathological findings.
Main Results:
- Of 116 Hurthle cell tumors, 49 were carcinoma. Frozen-section analysis diagnosed only 19% of Hurthle cell carcinomas accurately, with 75% being indeterminate.
- Tumor size correlated with malignancy (P=.0015), but gender did not.
- Men (67%) had a higher rate of malignancy than women (36%) with Hurthle cell neoplasm.
Conclusions:
- Intraoperative frozen-section analysis demonstrates limited accuracy in diagnosing Hurthle cell carcinoma.
- Gender and tumor size are important considerations in the evaluation of Hurthle cell neoplasms.