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Gene expression profiling within the developing neural tube.

Richard H Finnell1, Wade M Junker, Lisa Kvist Wadman

  • 1Institute of Biosciences and Technology, Texas A & M University System Health Science Center, Houston, TX 77030-3303, USA. rfinnell@ibt.tamu.edu

Neurochemical Research
|December 5, 2002
PubMed
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Neural tube defects (NTDs) are common congenital malformations. Research using mouse models explores genetic factors influencing neural tube closure (NTC) to understand causes of birth defects like anencephaly and spina bifida.

Area of Science:

  • Developmental biology
  • Genetics
  • Neuroscience

Background:

  • Congenital malformations of the mammalian nervous system incur significant global healthcare costs.
  • Neural tube defects (NTDs) are prevalent human birth defects with incompletely understood causes.
  • The complexity of genetic regulation during neurulation hinders understanding of NTDs.

Purpose of the Study:

  • To investigate the genetic factors influencing normal neural tube closure (NTC).
  • To identify genetic factors predisposing embryos to NTDs such as anencephaly and spina bifida.
  • To examine the impact of altered gene expression on neural tube development.

Main Methods:

  • Utilized mouse model systems, including spontaneous and genetically modified mutants.

Related Experiment Videos

  • Applied modern molecular biological technologies.
  • Examined the effects of teratogenic agents on neural tube development.

    • Main Results:

    • Gained greater appreciation for factors regulating normal NTC.
    • Identified genetic factors contributing to NTDs.
    • Demonstrated the impact of altered gene expression patterns on the developing neural tube.

    Conclusions:

    • Mouse models are valuable for studying the genetic basis of NTDs.
    • Understanding gene expression is crucial for preventing birth defects like anencephaly and spina bifida.
    • Further research into genetic factors can elucidate NTD etiology.