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A comparative review of cutaneous pH
Jennifer L Matousek1, Karen L Campbell
1Veterinary Clinical Medicine, University of Illinois, 1008 W. Hazelwood Drive, Urbana, IL 61802, USA. jmatousek@cvm.uiuc.edu
Veterinary Dermatology
|December 5, 2002
Summary
Skin pH is crucial for its structure and function, influencing microbiota, infection defense, and keratinization. This review explores the factors, variations, and functions of skin acidity and alkalinity.
Area of Science:
- Dermatology
- Biochemistry
- Microbiology
Background:
- The skin's surface possesses a unique acidic pH, known as the 'acid mantle'.
- This acidity is maintained by various molecules and exhibits variations across species, individuals, and within individuals.
Purpose of the Study:
- To review the role of pH in skin structure and function.
- To analyze the functions of cutaneous pH in both healthy and diseased states.
- To explore the impact of pH on skin microbiota and keratinization.
Main Methods:
- Literature review of studies on cutaneous pH.
- Analysis of molecular contributors to skin acidity/alkalinity.
- Examination of pH variations and functional implications.
Main Results:
- Cutaneous pH influences the selection and maintenance of the skin's normal microbiota.
- Skin acidity provides protection against microbial infections.
- A cutaneous pH gradient is essential for activating pH-dependent enzymes in keratinization.
Conclusions:
- Skin pH is a critical factor in maintaining skin homeostasis and barrier function.
- Understanding cutaneous pH is vital for diagnosing and treating skin conditions.
- Further research into pH-dependent processes can lead to novel therapeutic strategies.