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Related Experiment Videos

Brain glucose utilization in undernourished rats.

H P Chase, D O Rodgerson, W Lindsley

    Pediatric Research
    |February 11, 1976
    PubMed
    Summary

    Undernourished rat pups show reduced glucose incorporation into brain lipids and amino acids. Key brain energy metabolism enzymes like glutamate dehydrogenase were also significantly lower in undernourished pups.

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    Area of Science:

    • Biochemistry
    • Neuroscience
    • Developmental Biology

    Background:

    • Early life nutrition significantly impacts brain development and function.
    • Understanding metabolic adaptations during undernutrition is crucial for identifying developmental deficits.

    Purpose of the Study:

    • To investigate the effects of undernutrition on glucose metabolism and key enzyme activities in the developing rat brain.
    • To assess alterations in brain glucose, glycogen, ATP, and amino acid concentrations.

    Main Methods:

    • In vivo incorporation of radioactivity from [U-14C]glucose into brain lipids and amino acids.
    • Measurement of brain glucose, glycogen, ATP, and phosphocreatine concentrations.
    • Assay of brain mitochondrial and supernatant enzyme activities, including glutamate dehydrogenase, isocitrate dehydrogenase, and pyruvate kinase.

    Main Results:

    • Undernutrition reduced [U-14C]glucose incorporation into brain lipids (ages 6, 10, 17 days) and amino acids (age 10 days).
    • Lower brain glucose concentrations were observed at day 20 in undernourished pups.
    • Brain mitochondrial glutamate dehydrogenase activity was decreased by 21% (10 days) and 30% (20 days) in undernourished rats.
    • Brain glycogen levels were higher in fetal and newborn controls compared to older animals.

    Conclusions:

    • Early life undernutrition impairs glucose utilization for lipid and amino acid synthesis in the developing rat brain.
    • Reduced glutamate dehydrogenase activity suggests altered amino acid metabolism under nutritional stress.
    • Brain energy metabolite levels show developmental increases from fetus to newborn, with limited further changes.

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