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Updated: May 2, 2026
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Template-assisted preferential formation of a syn photodimer in a pyrophosphate-induced self-assembly of a
Yuichi Kato1, Seiichi Nishizawa, Norio Teramae
1Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.
Abstract:
[reaction: see text] The effect of anion templation is investigated for the photodimerization of a thymine-functionalized isothiouronium receptor. The receptor forms a photodimer at the thymine moiety in methanol upon UV irradiation, while the isothiouronium moiety works as an oxoanion binding site via a two-point hydrogen-bonding motif. As compared to the case of a free receptor, the presence of pyrophosphate (PPi) resulted in the preferential formation of the syn-type photodimer, which would be desirable for recognizing the templated PPi.
