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The stereocontrolled total synthesis of (-)-O-methylpallidinine
Keisuke Hanada1, Norio Miyazawa, Kunio Ogasawara
1Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan.
Organic Letters
|December 6, 2002
Abstract:
[reaction: see text] The stereocontrolled total synthesis of (-)-O-methylpallidinine, a naturally occurring Morphinan alkaloid with a B/C-trans-hydrophenanthrene framework, has been achieved starting from the chiral bicyclo[3.2.1]octenone building block by employing a single-step dihydrophenanthrene formation reaction as the key step.