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Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives
Laure Cointeaux1, Jean-François Berrien, Viviane Peyrou
1UPRES A 8076 BioCIS, Laboratoire de synthèse et conception des molécules d'intérêt thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay Malabry Cedex, France.
Bioorganic & Medicinal Chemistry Letters
|December 7, 2002
Abstract:
2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn(II)-TPP.