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Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents
Hsing-Pang Hsieh1, Jing-Ping Liou, Ying-Ting Lin
1Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 9F, 161, Sec. 6, Min-Chiuan East Road, Taipei 114, Taiwan, ROC. hphsieh@nhri.org.tw
Bioorganic & Medicinal Chemistry Letters
|December 7, 2002
Abstract:
Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.