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Central and peripheral chemoreflexes in panic disorder.

Martin A Katzman1, Lukasz Struzik, Nishka Vijay

  • 1Anxiety Disorders Clinic, Centre for Addiction and Mental Health-Clarke Division, 250 College Street, Toronto, Ontario, Canada M5T 1R8. martin_katzman@camh.net

Psychiatry Research
|December 7, 2002
PubMed
Summary
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This study found no difference in carbon dioxide detection thresholds between panic disorder patients and healthy individuals. The results do not support the false suffocation alarm theory for panic disorder.

Area of Science:

  • Respiratory Physiology
  • Clinical Psychology
  • Neuroscience

Background:

  • Klein's hypothesis suggests panic disorder involves a false suffocation alarm linked to reduced carbon dioxide detection.
  • This study investigates the chemoreflex thresholds in panic disorder patients to evaluate this hypothesis.

Purpose of the Study:

  • To compare central and peripheral chemoreflex thresholds and sensitivities between panic disorder patients and healthy volunteers.
  • To test the validity of Klein's "false suffocation alarm" theory regarding panic disorder.

Main Methods:

  • Utilized a modified Read's rebreathing technique in 11 panic disorder patients and 10 healthy volunteers.
  • Assessed central chemoreflex alone (hyperoxic test) and combined central and peripheral chemoreflex (hypoxic test).

Related Experiment Videos

  • Retrospectively assessed panic symptoms using a DSM-IV derived Panic Symptom Scale.

    • Main Results:

    • No significant differences were observed in chemoreflex sensitivities or thresholds between panic disorder patients and healthy volunteers.
    • Panic symptoms did not correlate with altered respiratory chemoreflex responses.

    Conclusions:

    • The findings do not support Klein's hypothesis that a false suffocation alarm in panic disorder is mediated by respiratory chemoreflexes.
    • If a false suffocation alarm exists in panic disorder, its mechanism likely lies outside the respiratory chemoreflex system.