Molecular strategies in Metazoan genomic evolution
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Updated: Sep 28, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
Cecilia Saccone1, Pierre Olivier Barome, Anna Maria D'Erchia
1Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi, via Orabona 4, Bari, Italy. saccone@area.ba.cnr.it
Abstract:
During the evolution of Metazoa, the mitochondrial genome has remained practically unchanged as indicated by its small size and constant gene content in each lineage, although several evolutionary processes have taken place. In contrast, the nuclear genome of Metazoa has undergone dramatic changes, as is demonstrated by some entire genomes completely sequenced so far. The expansion of gene families and the appearance of new functions and new regulatory circuits are among the most prominent features. Here, we report a description of the evolution of the p53 gene family as an example of expansion of both genetic complexity and gene expression of the nuclear genome.
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