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Alkylaminopropenones and alkylamino-propenoates as efficient and versatile synthons in microwave-assisted
J Westman1, R Lundin, J Stålberg
1Personal Chemistry AB, Kungsgatan 76, Uppsala, 753 18, Sweden. jacob.westman@personalchemistry.com
Combinatorial Chemistry & High Throughput Screening
|December 10, 2002
Abstract:
A simple and fast one-pot method using microwave irradiation for the synthesis of a number of small libraries of diverse heterocycles is described in this paper. The two-step one-pot method includes the formation of alkylaminopropenones or alkylaminopropenoates in 5 min at 180 degrees C and a subsequent treatment with dinucleophiles for 3 to 5 min at 150 degrees C to 180 degrees C to form a variety of biologically interesting heterocycles in a cascade-type reaction. The combination of combinatorial chemistry and microwave-assisted synthesis was found to be very efficient.