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Transient movement disorders and multiple sclerosis
Alireza Minagar1, William A Sheremata, William J Weiner
1Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, P.O. Box 33932, Shreveport 71130-3932, USA. aminagar@aol.com
Parkinsonism & Related Disorders
|December 11, 2002
Summary
Movement disorders like dystonia and chorea are rare in multiple sclerosis (MS), but can occur during relapses. These symptoms improved with adrenocorticotropin hormone (ACTH) treatment.
Area of Science:
- Neurology
- Neuroimmunology
- Movement Disorders
Background:
- Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
- Movement disorders are infrequent in MS, with tremor being the most common exception.
- The pathophysiology of MS involves demyelination and neuroinflammation, leading to diverse clinical manifestations.
Observation:
- Two cases of relapsing-remitting MS (RRMS) are presented.
- Patients experienced new-onset dystonia or chorea during acute clinical exacerbations.
- These involuntary movements were temporally associated with MS relapses.
Findings:
- The observed movement disorders, dystonia and chorea, were transient.
- Symptoms resolved following treatment with adrenocorticotropin hormone (ACTH).
- This suggests a potential link between MS exacerbations and specific movement abnormalities.
Implications:
- Acute MS exacerbations can manifest with uncommon movement disorders.
- Adrenocorticotropin hormone (ACTH) therapy may be effective in managing these transient neurological symptoms.
- Highlights the importance of considering movement disorders in the differential diagnosis during MS relapses.