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Updated: Sep 28, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
Published on: February 15, 2019
Gene therapy in the post-Gelsinger era
Lynn Smith1, Jacqueline Fowler Byers
1University of Central Florida, School of Nursing, Orlando 32816, USA. lcsmith@mail.ucf.edu
Abstract:
As gene therapy research races to a first cure of a genetic-based disease, the research community has struggled with the aftermath of the well-publicized death of Jesse Gelsinger from complications of an experimental treatment. In a wrongful death lawsuit against the University of Pennsylvania and its researchers, Jesse Gelsinger's family alleged violations of federal regulations and research ethics. This article reviews gene therapy research, examines the role of the key players in this tragedy, and provides suggestions for preventing future misfortunes.
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