Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asthma remission: does it exist?

Leon M van den Toorn1, Shelley E Overbeek, Jan-Bas Prins

  • 1Department of Pediatrics/Pediatric Respiratory Medicine, Erasmus MC, Rotterdam, the Netherlands. Lvandentoorn@planet.nl

Current Opinion in Pulmonary Medicine
|December 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sotatercept in TBX4 Associated Heritable Pulmonary Arterial Hypertension: A Case Report of a Super Responder.

Pulmonary circulation·2026
Same author

A framework for assessing practical competence in laboratory animal science (LAS): development of direct observation of procedural skills (DOPS) by the ETPLAS Working Group.

Laboratory animals·2026
Same author

Sixty Years of Laboratory Animals.

Laboratory animals·2026
Same author

Vocalisations as a potential indicator of parturition in C57BL/6J mice.

Animal welfare (South Mimms, England)·2025
Same author

Inoperable chronic thromboembolic pulmonary hypertension: Evolution of prognosis over 10 years of new emerging therapies.

Pulmonary circulation·2024
Same author

Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research.

PLoS biology·2024
Same journal

Nonsteroid treatment options in (pulmonary) sarcoidosis. When to consider and why?

Current opinion in pulmonary medicine·2026
Same journal

Multidisciplinary approach in cardiac sarcoidosis: to biopsy or not?

Current opinion in pulmonary medicine·2026
Same journal

Low diffusion capacity in pulmonary hypertension.

Current opinion in pulmonary medicine·2026
Same journal

Toward precision imaging in interstitial lung disease: advances in quantitative imaging and artificial intelligence.

Current opinion in pulmonary medicine·2026
Same journal

Oxygen therapy in interstitial lung disease - navigating benefit and burden.

Current opinion in pulmonary medicine·2026
Same journal

Preclinical and clinical advances in pulmonary hypertension associated with systemic sclerosis.

Current opinion in pulmonary medicine·2026
See all related articles

Asthma may return later in life due to ongoing airway inflammation and remodeling, even in those who seem to have outgrown it. Further research is needed to see if long-term anti-inflammatory therapy can improve asthma remission rates.

Area of Science:

  • Pulmonology
  • Immunology
  • Allergy

Background:

  • Many individuals who believe they have outgrown asthma experience symptom recurrence later in life.
  • Chronic airway inflammation during childhood asthma can lead to irreversible airway remodeling and airflow obstruction.
  • Recent studies show airway inflammation and remodeling persist in young adults who consider their asthma resolved.

Purpose of the Study:

  • To investigate the persistence of airway inflammation and remodeling in adults with a history of childhood asthma.
  • To explore the potential for noninvasive monitoring of airway inflammation and remodeling.
  • To examine whether prolonged anti-inflammatory therapy can alter the natural history of asthma and improve long-term prognosis.

Main Methods:

  • Analysis of bronchial biopsy specimens from young adults with a history of asthma.

Related Experiment Videos

  • Development and application of noninvasive methods to detect airway inflammation and remodeling.
  • Review of epidemiologic data on asthma remission and the impact of anti-inflammatory therapy.

    • Main Results:

    • Airway inflammation and remodeling were detected in young adults who believed they had outgrown asthma.
    • Noninvasive techniques can identify evidence of airway inflammation and remodeling, allowing for disease monitoring.
    • The long-term benefits of prolonged anti-inflammatory therapy on asthma prognosis are not yet established.

    Conclusions:

    • Airway inflammation and remodeling may persist in individuals with a history of childhood asthma, even when asymptomatic.
    • Noninvasive monitoring of these markers is feasible and could aid in disease management.
    • The potential to increase asthma remission rates through prolonged anti-inflammatory therapy requires further investigation.