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Related Experiment Videos

Naturally and externally pulsed electrospray.

Junfei Wei1, Wenqing Shui, Feng Zhou

  • 1Department of Chemistry, Fudan University, Shanghai 200433, China.

Mass Spectrometry Reviews
|December 12, 2002
PubMed
Summary

Pulsation phenomena in electrospray ionization (ESI) involve low-frequency and high-frequency processes. Electrical control of these pulsations can enhance sensitivity and signal-to-noise ratio in mass spectrometry analysis.

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Electrospray ionization (ESI) is a crucial technique for generating ions from liquid samples.
  • Pulsation phenomena in ESI can significantly impact analytical performance.
  • External electrical control offers a method to modulate these pulsations.

Purpose of the Study:

  • To review existing studies on pulsation phenomena in electrospray ionization.
  • To discuss the fundamental and experimental aspects of low-frequency and high-frequency pulsations.
  • To explore the potential of electrical control for pulsed ESI applications.

Main Methods:

  • Review of fundamental principles governing ESI pulsations.
  • Analysis of experimental investigations into low and high-frequency pulsation mechanisms.

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  • Examination of electrical control strategies for pulsed ESI.

    • Main Results:

    • Two primary pulsation types identified: low-frequency fluctuation and high-frequency droplet formation.
    • Low-frequency pulsation arises from flow rate imbalances in the Taylor cone.
    • High-frequency pulsation originates from initial droplet formation and is influenced by low-frequency pulsation.

    Conclusions:

    • Electrical control of both low and high pulsations enables pulsed ESI.
    • Pulsed ESI can lead to enhanced sensitivity and signal-to-noise ratios.
    • Further research is needed for synchronizing natural pulsations with pulsed ESI for mass spectrometry applications.