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Preparation and study on the solid inclusion complex of ciprofloxacin with beta-cyclodextrin
Chao Jianbin1, Chen Liang, Xu Hao
1The Test and Analysis Center of Shanxi University, Tai Yuan 030006, PR China.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|December 13, 2002
Summary
Ciprofloxacin forms a 1:1 inclusion complex with beta-cyclodextrin (betaCD), confirmed by various analytical methods. This study details the synthesis and characterization of this novel drug delivery complex.
Area of Science:
- Pharmaceutical Chemistry
- Supramolecular Chemistry
- Analytical Chemistry
Background:
- Ciprofloxacin is a widely used fluoroquinolone antibiotic.
- Beta-cyclodextrin (betaCD) is a cyclic oligosaccharide known for its ability to form inclusion complexes.
- Drug complexation can enhance solubility, stability, and bioavailability.
Purpose of the Study:
- To synthesize and characterize a solid inclusion complex of ciprofloxacin with beta-cyclodextrin.
- To investigate the interaction and stoichiometry of the ciprofloxacin-betaCD complex.
- To determine the formation constant and proposed spatial configuration of the complex.
Main Methods:
- Coprecipitation method for complex synthesis.
- Characterization using fluorescence spectroscopy, IR spectroscopy, differential scanning calorimetry (DSC).
- Structural analysis via 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy (1H-NMR, 13C-NMR).
Main Results:
- The coprecipitation method successfully yielded a solid inclusion complex.
- Experimental data confirmed a 1:1 stoichiometric ratio between ciprofloxacin and beta-cyclodextrin.
- Formation constant was quantified using fluorescence and 1H-NMR.
- Two-dimensional NMR provided insights into the spatial configuration of the complex.
Conclusions:
- A stable 1:1 inclusion complex of ciprofloxacin with beta-cyclodextrin was successfully synthesized and characterized.
- The study provides a foundation for developing improved ciprofloxacin formulations.
- Understanding the complexation mechanism is crucial for optimizing drug delivery systems.