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Postmenopausal hormone replacement therapy and the prevention of cardiovascular disease: a review

Beth L Abramson1

  • 1Division of Cardiology, Department of Medicine, St. Michael's Hospital and University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada. abramsonb@smh.toronto.on.ca

Journal of Cardiovascular Risk
|December 13, 2002
PubMed

Insights

Hormone replacement therapy (HRT) shows minimal benefit for preventing cardiac disease in women. Current evidence indicates HRT is not recommended for primary or secondary cardiac disease prevention.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology

Background:

  • The role of hormone replacement therapy (HRT) in cardiovascular disease (CVD) prevention remains a subject of debate.
  • Epidemiological evidence regarding HRT's impact on primary and secondary CVD prevention requires careful assessment.

Purpose of the Study:

  • To critically evaluate the epidemiological evidence for HRT's role in the primary and secondary prevention of cardiac disease.
  • To determine the current indications for HRT concerning cardiac health.

Main Methods:

  • Systematic review of epidemiological studies.
  • Assessment of evidence for HRT in women with and without established cardiovascular disease.

Main Results:

  • Current studies indicate a very limited role for HRT in women with existing cardiac disease.
  • The benefit of HRT for cardiac prevention in healthy women without vascular disease was previously unclear but is now addressed.

Conclusions:

  • Hormone replacement therapy (HRT) is not indicated for the sole purpose of preventing cardiac disease.
  • Clinical guidelines should reflect the lack of evidence supporting HRT for cardiac prevention.

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