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The olfactory bulb as an independent developmental domain
L López-Mascaraque1, F de Castro
1Instituto Cajal-C.S.I.C., Madrid, Spain. mascaraque@cajal.csic.es
Cell Death and Differentiation
|December 13, 2002
Summary
The olfactory system
Area of Science:
- Neuroscience
- Developmental Biology
Background:
- The olfactory system provides a model for studying axonal guidance mechanisms.
- Olfactory bulb formation involves cell differentiation and gene expression patterns.
- Interactions between olfactory epithelium, bulb, and cortex are of developmental interest.
Purpose of the Study:
- To correlate data from developmental studies on the olfactory system.
- To gain insight into mechanisms of olfactory system specification and development.
- To review molecular cues in olfactory bulb to olfactory cortex projection formation.
Main Methods:
- Review of existing developmental studies.
- Analysis of gene expression patterns.
- Studies in pax6 mutant mice (Sey(Neu)/Sey(Neu)).
Main Results:
- Initial olfactory bulb central projections can form independently of olfactory sensory axons.
- The pax6 mutation impacts olfactory bulb development.
Conclusions:
- The olfactory bulb's capacity for independent projection establishment is demonstrated.
- Further investigation is needed regarding the olfactory bulb as an independent developmental domain.