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Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor
Patricia Laplante1, Josie Diorio, Michael J Meaney
1Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry and Neurology & Neurosurgery, McGill University, 6875 Boul. LaSalle, Quebec, Montréal, Canada H4H 1R3.
Brain Research. Developmental Brain Research
|December 14, 2002
Abstract:
Glucocorticoid receptor expression in primary hippocampal cell cultures was significantly increased with either 10 mM 8-bromo cAMP, 50 nM 5-carboxamidotryptamine (5-CT), a potent 5-HT7 receptor agonist, or 100 nM 5-HT. The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor.