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Esomeprazole: update and clinical review
1College of Pharmacy, Washington State University, Spokane, Washington, USA.
Reviews in Gastroenterological Disorders
|December 14, 2002
Summary
Omeprazole may soon be available over-the-counter for frequent heartburn. Consumer studies suggest most people can understand its labeling for appropriate use. Esomeprazole remains effective for GERD and erosive esophagitis.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Gastroesophageal reflux disease (GERD) and erosive esophagitis are common conditions.
- Proton pump inhibitors (PPIs) are widely used for treatment.
Purpose of the Study:
- To evaluate the potential for over-the-counter (OTC) omeprazole for heartburn.
- To review the efficacy and safety of esomeprazole and compare it with other PPIs.
Main Methods:
- Review of consumer studies on OTC omeprazole labeling.
- Analysis of recent clinical studies on esomeprazole and other PPIs.
Main Results:
- Advisory committees recommended OTC omeprazole approval based on consumer understanding.
- Esomeprazole demonstrates continued efficacy and safety for GERD and erosive esophagitis.
- Comparative studies show all PPIs are effective, with some patients benefiting from esomeprazole.
Conclusions:
- OTC omeprazole shows promise for accessible heartburn treatment.
- Esomeprazole is a valuable option within the effective class of PPIs for GERD management.