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Lympho-hemopoietic malignancies in India.
Manisha Bhutani1, Amish Vora, Lalit Kumar
1Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Medical Oncology (Northwood, London, England)
|December 17, 2002
Summary
Lympho-hemopoietic malignancies in India show lower incidence than in the West, but chronic myelogenous leukemia is higher. Cancers occur younger, with rising non-Hodgkin
Area of Science:
- Hematology
- Oncology
- Epidemiology
Background:
- Lympho-hemopoietic malignancies represent a significant global health concern.
- Understanding cancer epidemiology in diverse populations like India is crucial for targeted interventions.
Purpose of the Study:
- To present available information on lympho-hemopoietic malignancies in India.
- To compare the incidence and characteristics of these cancers with Western populations.
Main Methods:
- Review and synthesis of existing data on lympho-hemopoietic malignancies in India.
- Comparative analysis of incidence rates, age of onset, and specific subtypes between India and Western countries.
Main Results:
- Lower overall incidence of multiple myeloma, lymphomas, and leukemias compared to the West.
- Higher incidence of chronic myelogenous leukemia and a rising trend in non-Hodgkin's lymphoma (NHL).
- Predominance of younger age at diagnosis, higher frequency of specific subtypes (mixed-cellularity Hodgkin's disease, diffuse large-cell NHL, T-cell acute lymphoblastic leukemia), advanced stage at presentation, and poorer prognostic factors.
Conclusions:
- Lympho-hemopoietic malignancies in India exhibit distinct epidemiological patterns compared to Western populations.
- Despite challenges like younger age at diagnosis and advanced stages, treatment outcomes are comparable when adjusted for prognostic factors.