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Dihydropyrimidinones--a new class of anti-staphylococcal antibiotics
Michael Brands1, Rainer Endermann, Reinhold Gahlmann
1BAYER AG, Business Group Pharma, Research, D-42096 Wuppertal, Germany.
Bioorganic & Medicinal Chemistry Letters
|December 17, 2002
Abstract:
We report the synthesis and pharmacological evaluation of new derivatives of natural dipeptide antibiotic TAN-1057 A, B. In the course of this program, we identified novel analogues of the natural product that display similar antibacterial activity and showed improved tolerability.