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beta-Homolysine oligomers: a new class of Trojan carriers
C García-Echeverría1, Stephan Ruetz
1Oncology Research, Novartis Pharma Inc., CH-4002 Basel, Switzerland. c.garcía-echeverría@pharma.novartis.com
Bioorganic & Medicinal Chemistry Letters
|December 17, 2002
Abstract:
We describe the design, synthesis and cell-membrane translocation properties of a series of beta-peptides with the general sequence fluorescein-Adoa-(beta-homolysine)(n)-NH(2), n=5-8 and Adoa=8-amino-3,6-dioxaoctanoic acid. These beta-peptides are able to cross the cytoplasmic membrane and accumulate in the nucleus of mammalian cells.