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Drugs targeting functional bowel disorders: insights from animal studies
Gareth J Sanger1, Gareth A Hicks
1Neurology and Gastroenterology-CEDD, GlaxoSmithKline, Harlow, Essex, UK. Gareth_J_Sanger@gsk.com
Current Opinion in Pharmacology
|December 17, 2002
Abstract:
Increased understanding of gastrointestinal pathophysiology in functional bowel disorders is leading to improved focus on relevant enteric, vagal and spinal afferent nervous systems, and targets operating on these systems. These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing factor and somatostatin.