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Structural proteomics: lessons learnt from the early case studies
Martin Norin1, Michael Sundström
1Biovitrum, Department of Structural Chemistry, Nordenflychtsvägen 62:6, SE-112 76 Stockholm, Sweden. martin.norin@biovitrum.com
Farmaco (Societa Chimica Italiana : 1989)
|December 18, 2002
Summary
Genomics has uncovered many new proteins. Structural proteomics offers a way to understand protein function by analyzing their 3D structures, aiding in gene and protein characterization.
Area of Science:
- Structural biology
- Genomics
- Proteomics
Background:
- Genomics initiatives have identified numerous novel genes and target proteins lacking functional characterization.
- Understanding protein function is crucial for biological and medical research.
Purpose of the Study:
- To highlight the impact of structural proteomics on functional characterization of novel proteins.
- To discuss the role of structure-function hypotheses in accelerating biological discovery.
Main Methods:
- Analysis of protein structures using fold and feature recognition.
- Review of current structural proteomics initiatives and their outputs.
- Examination of individual studies demonstrating structure-based function derivation.
Main Results:
- Structural proteomics provides a roadmap for inferring protein function from 3D structures.
- Despite rapid structure generation, large-scale public data remains limited.
- Individual studies show promise in linking protein structure to function.
Conclusions:
- Structural proteomics is key to unlocking the functional potential of newly identified genes.
- Developing robust structure-function relationships will accelerate biological research.
- Increased accessibility of structural data is needed to maximize impact.