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Updated: Jul 30, 2026
09:43
Microfluidic Chip Fabrication and Method to Detect Influenza
Published on: March 26, 2013
Microchip electrophoresis-based separation of DNA.
Lihua Zhang1, Fuquan Dang, Yoshinobu Baba
1Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima, CREST, Japan Science and Technology Corporation (JST), Shomachi, Tokushima 770-8505, Japan. lzhang@ph.tokushima-u.ac.jp
Journal of Pharmaceutical and Biomedical Analysis
|December 18, 2002
Summary
Microchip electrophoresis offers rapid DNA separation using miniaturized technology. This review covers chip design, fluid control, detection, and applications in genetic analysis and DNA sequencing.
Area of Science:
- Biotechnology
- Analytical Chemistry
- Genomics
Background:
- Miniaturized instruments have advanced significantly.
- Microchip electrophoresis (ME) is a key technology for DNA analysis.
Purpose of the Study:
- To review the fundamentals of microchip electrophoresis for DNA separation.
- To highlight advancements and applications in DNA analysis.
Main Methods:
- Summarized chip formats, substrates, and fabrication technologies.
- Detailed fluid control and various detection methods.
- Introduced array electrophoresis microchips and integrated systems.
Main Results:
- Covered essential components and operational principles of ME devices.
- Presented on-chip integration of electrophoresis with other systems.
- Demonstrated applications in DNA sizing, genetic analysis, and sequencing.
Conclusions:
- Microchip electrophoresis is a powerful tool for diverse DNA analyses.
- Ongoing developments promise further advancements in genomic research.
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