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Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis
Sandrine Lépine1, Boris Lakatos, Pierre Maziere
1Biomembranes et Messagers Cellulaires, CNRS -UMR 8619, Université Paris XI, France.
Annals of the New York Academy of Sciences
|December 18, 2002
Abstract:
It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone-induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase-dependent manner.