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Homocysteine and risk of open-angle glaucoma
S Bleich1, A Jünemann, N von Ahsen
1Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University, Schwabachanlage 6-10, D-91054 Erlangen-Nuremberg, Federal Republic of Germany. stefan.bleich@psych.imed.uni-erlangen.de
Journal of Neural Transmission (Vienna, Austria : 1996)
|December 18, 2002
Abstract:
Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.