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Urinary kallikrein in hypertensive animal models
Federation Proceedings
|February 1, 1976
Summary
Urinary kallikrein excretion varied in animal hypertension models, decreasing with some hypertension types and increasing with others. This suggests the kallikrein-kinin system may influence hypertension development.
Area of Science:
- Nephrology
- Endocrinology
- Cardiovascular Research
Background:
- The kallikrein-kinin system is a potent vasodilator with a potential role in blood pressure regulation.
- Understanding its function in hypertension is crucial for developing new therapeutic strategies.
Purpose of the Study:
- To investigate urinary kallikrein excretion patterns in various animal models of hypertension.
- To determine the correlation between kallikrein excretion and factors like sodium balance, renal blood flow, and hormonal influences.
Main Methods:
- Studied urinary kallikrein excretion in spontaneously hypertensive rats, renal artery-clipped rats, desoxycorticosterone-treated rats, and adrenalectomized rats.
- Examined kallikrein excretion in normotensive rats on varying sodium diets.
- Analyzed kallikrein excretion in dogs with renal artery stenosis.
Main Results:
- Subnormal kallikrein excretion was observed in spontaneously hypertensive rats and renal artery-clipped rats.
- Supranormal kallikrein excretion occurred in desoxycorticosterone-induced hypertension models.
- Kallikrein excretion increased with low-sodium diets but was unaffected by high-sodium diets.
- Decreased kallikrein excretion in dogs with renal artery stenosis correlated with reduced renal blood flow.
Conclusions:
- Urinary kallikrein excretion is modulated by sodium-retaining steroids and renal blood flow, not directly by salt or water excretion.
- The kidney's kallikrein-kinin system may play a significant role in the initiation and maintenance of hypertension.