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Clinical cases in transplantation
1Harvard Medical School, Transplant Infectious Diseases and Compromised Host Program, Infectious Disease Division and Transplant Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. jfishman@partners.org
Summary
Caring for immunocompromised patients with invasive fungal infections is complex. Expert discussions highlight controversies and future research needs for transplant recipients.
Area of Science:
- Medical Mycology
- Immunocompromised Host Research
- Transplant Infectious Diseases
Background:
- Invasive fungal infections (IFIs) pose significant challenges in immunocompromised patients.
- Management of IFIs in transplant recipients requires specialized, multidisciplinary care.
- Current treatment strategies often face complexities and uncertainties.
Observation:
- A series of clinical cases illustrate the intricate nature of managing IFIs.
- Expert panel discussions convened to address these complex cases.
- Key areas of clinical controversy were identified.
Findings:
- The care of immunocompromised patients with IFIs is multifaceted.
- Established IFIs in transplant recipients present unique management dilemmas.
- Discussions identified specific areas requiring further investigation and consensus.
Implications:
- Highlights the need for improved diagnostic and therapeutic approaches for IFIs.
- Informs future research directions in antifungal therapy and patient management.
- Aims to enhance outcomes for immunocompromised individuals, particularly transplant recipients.