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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
[Sensory neuropathy and primary biliary cirrhosis]
S Escalante1, J Arpa, F Sebastián de la Cruz
1Servicios de Neurología, Hospital Universitario La Paz, Madrid, España.
Neurologia (Barcelona, Spain)
|December 19, 2002
Summary
Primary biliary cirrhosis (PBC) can cause neuropathy. This case study details a patient with PBC and a slowly progressing, asymmetric sensory neuropathy affecting only the upper limbs.
Area of Science:
- Hepatology
- Neurology
- Clinical Case Study
Background:
- Primary biliary cirrhosis (PBC) is an autoimmune liver disease.
- PBC can be associated with various neuropathies, including axonal, somatic, autonomic, and sensory types.
- Sensory neuropathy is an infrequent complication of PBC.
Observation:
- A 46-year-old male diagnosed with early-stage PBC presented with progressive sensory neuropathy.
- The neuropathy was exclusively confined to the upper limbs, exhibiting distal predominance.
- Onset was asymmetric and slow, with no other identifiable causes of neuropathy.
Findings:
- The patient's sensory neuropathy was characterized as an axonopathy.
- Clinical and electrophysiological evaluations confirmed the neuropathy's association with PBC.
- The condition remained stable over a two-year follow-up period.
Implications:
- This case highlights a rare presentation of sensory neuropathy in PBC.
- It underscores the importance of considering neuropathy in PBC patients, even with atypical presentations.
- Further research may elucidate the specific mechanisms linking PBC to asymmetric upper limb sensory neuropathy.
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